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. 2021 Apr 13;12:2193. doi: 10.1038/s41467-021-22497-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Final homology model of EryAT6 containing both linkers. The catalytic dyad is shown as sticks with the distance between indicated with a dashed orange line. b Overlay of time-averaged structures from the EryAT6 wild-type and mutant simulations highlighting the distortion of the small subunit. c A box plot shows how the distance between the catalytic dyad varied over simulation time for each EryAT6 variant. d A box plot shows how the distance between the center of mass for the SSM and LSM varied over simulation time for each EryAT6 variant. The X indicates the mean. The boxes represent the range from the first to third quartiles with the center line representing the median. The whiskers represent the minima and maxima or, in the presence of outliers indicated by points, 1.5 times the interquartile range. These distances were measured every 0.1 ns over the final 80 ns (n = 800) of two independent simulations. WT = wild-type. Source data are provided as a Source Data file.