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. 2021 Apr 13;11:8076. doi: 10.1038/s41598-021-87470-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Profile plots on the natural log scale. Profile plot (per-mouse intraperitoneal tumor area trajectories measured via ultrasound) for all five Case Study PDX models on the natural log scale used for modeling. Coloring indicates drug arm: control (diluent), chemo (carboplatin + paclitaxel), the PARPi niraparib (MK), or chemo + MK (carboplatin + paclitaxel + MK). Lines connect observations from the same mouse provide a visual check of balance at baseline (day = 0), a sense of whether growth trajectories are straight or curved (functional form), and the magnitude of between mouse variation and attrition. Per arm sample sizes at day 0 for each PDX model are as follows: PH80: control n = 5, chemo n = 8, MK n = 5, MK + chemo n = 7; PH87: control n = 5, chemo n = 9, MK n = 5, MK + chemo n = 7; PH77: control n = 10, chemo n = 10, MK n = 5, MK + chemo n = 9; PH95: control n = 5, chemo n = 6, MK n = 5, MK + chemo n = 6; PH39: control n = 5, chemo n = 8, MK n = 5, MK + chemo n = 7.