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. 2021 Apr 13;11:8076. doi: 10.1038/s41598-021-87470-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Model estimates of growth trajectories for each PDX model. Coloring indicates drug arm. Predicted lines are the average estimates computed from the statistical model fixed effects, relative to the arm specific baseline estimate. The forms of the statistical mean models are the following: PH80, PH87: straight; PH77, PH95: quadratic; PH39: cubic. Shading indicates 95% confidence intervals. The number of mice under observation at each time point for each arm is indicated below the x-axis as a function of time, where text color indicates drug arm.