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. 2021 Apr 13;7:36. doi: 10.1038/s41531-021-00180-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Pathway analysis was conducted using Gene Set Enrichment Analysis (GSEA) and the human Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways in females (a) and males (b), separately. Genes ranked by the absolute value of the Wald test statistic generated by differential expression analysis between PD and HC were utilized in the analysis. The KEGG pathway name is labeled on the y-axis, the -log10 of the q-value is plotted on the x-axis, the line and dot plotted are colored by the normalized enrichment score (NES) with the highest NES plotted in red and the lowest (from the significant pathways plotted) in green. The size of the dot in the figure represents the number of genes from our input that were in that specific pathway.