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. 2021 Apr 13;7:36. doi: 10.1038/s41531-021-00180-z

Fig. 7. Classical M1 pro-inflammatory gene modules enriched for differences between PD and HC in female cohort but not male cohort.

Fig. 7

Gene Set Enrichment Analysis (GSEA) was performed separately for each sex. Enrichment results for Module 7 in females (a), enrichment results for Module 7 in males (b), enrichment for Module 8 in females (c), and enrichment results for Module 8 in males (d) are shown. Two gene modules (of the 49 tested) were enriched in females (Modules 7 and 8, FDR q-value < 0.001). Both are classical “M1” pro-inflammatory gene programs, and strongly associated with response to IFNγ. No gene modules achieved statistical significance in males. Genes in each individual module are labeled at the position in which they appear in the ranked gene list (ranked by the absolute value of the Wald test statistic value between PD and HC) for females and males.