Table 1.
Cohort characteristics.
| Variable | Cases, PD (n = 18) | Controls, HC (n = 16) | p-value |
|---|---|---|---|
| Males, n (%) | 11 (61.1%) | 10 (62.5%) | 1.00 |
| Age at Visit (mean ± SD) years | 61.1 ± 10.5 | 65.4 ± 9.7 | 0.21 |
| Caucasian race, n (%) | 18 (100%) | 15 (93.8%) | 0.47 |
| Family History of PD, n (%) | 5 (27.8%) | 0 (0%) | 0.046 |
| MDS UPDRS I (median [Q1, Q3]) | 8.5 [3.2, 10.8] | 3 [1, 4.2] | 0.01 |
| MDS UPDRS II (median [Q1, Q3]) | 6.5 [3.2, 9.8] | 0 [0, 0] | <0.0001 |
| MDS UPDRS III (median [Q1, Q3]) | 21.5 [13.2, 33.8] | 0 [0, 0] | <0.0001 |
| MDS UPDRS IV (median [Q1, Q3]) | 0 [0, 0] | 0 [0, 0] | NA1 |
| MDS UPDRS total (median [Q1, Q3]) | 34 [26.2, 48.8] | 3 [1, 5] | <0.0001 |
| MoCA total (median [Q1, Q3]) | 25 [24, 26.8] | 26.5 [26, 28] | 0.04 |
| PDQ39 total (median [Q1, Q3]) | 72 [42.5, 111] | 25 [18.5, 38.5] | 0.003 |
1MDS-UPDRS IV score was not tested for significance as all subjects had a score of 0.