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. 2021 Apr 14;6:149. doi: 10.1038/s41392-021-00537-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — AβOs promote NLRP3 inflammasome priming and assembly in the RPE. a RPE flat mounts, stained for zonula occludens-1 (ZO-1; red), of Nlrp3-GFP knock-in mice injected subretinally with AβOs show increased GFP expression (green) compared to RPE flat mounts of saline-injected mice, n = 6. b Subretinal injection of AβOs, but not PBS, induced increased ASC speck formation in ASC-Citrine^Flox/Best1-Cre+ mice. ASC-Citrine fusion proteins are detected as a green signal. Subretinal injection of AβOs did not induce ASC speck formation in ASC-Citrine^Flox mice, n = 6. c Higher magnification images of the observed ASC speck in RPE flat mounts of ASC-Citrine^Flox/Best1-Cre+ mice injected with subretinal AβOs demonstrate the size of the specks. Selected areas of interest highlighted by the yellow squares depict the magnified regions. Scale bars (50 μm)