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. 2021 Apr 13;11:8020. doi: 10.1038/s41598-021-87434-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Normative models of Alzheimer’s disease progression shown at 4 Alzheimer Age with estimated time until/from diagnosis. Bottom to top rows show alteration of brain glucose metabolism, hippocampus atrophy, cortical thinning and onset of cognitive decline. Black arrows and ellipses indicate some areas of great changes. Images were obtained using the freely available software FSLeyes v.0.22.6 (https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FSLeyes) and Paraview v.5.2.0 (www.paraview.org).