Table 1.

Significant associations of individual parameters with genetic, biological and environmental factors: effect sizes, confidence intervals at $95\%$, and adjusted p-values. Only adjusted p-values below $5\%$ significance level are shown. Time-shifts are in months, other quantities have no units. Directions of space-shift are not signed. The figures on the top of the column “hippocampal atrophy” reads: “atrophy of the left hippocampus progresses 1.27 times faster in women than in men, starts 33.6 months earlier, and the hippocampus shape is significantly different between men and women regardless of the disease stage”.

			Hypometabolism	Hippocampus atrophy (MRI)		Cortical thinning	cognitive decline
			(FDG-PET)	:Left hemisphere	Right hemisphere	(MRI)	(ADAS+MMSE)
Genetic	$\begin{array}{c}\text{sex}\hfill \\ \text{female vs. male}\hfill \end{array}$	Accel. factor		$\times 1.27\begin{array}{c}\text{CI}=[1.11,1.45]\\ p=2.26\text{e}-3^{\ast \ast }\end{array}$	$\times 1.26\begin{array}{c}\text{CI}=[1.08,1.45]\\ p=6.15-3^{\ast \ast }\end{array}$		$\times 1.46\begin{array}{c}\text{CI}=[1.10,1.92]\\ p=8.42\text{e}-3^{\ast \ast }\end{array}$
		Time-shift		$-33.6\begin{array}{c}\text{CI}=[-55.8,-11.6]\\ p=3.71\text{e}-3^{\ast \ast }\end{array}$	$-29.0\begin{array}{c}\text{CI}=[-53.0,-4.91]\\ p=2.31\text{e}-2^{\ast }\end{array}$		$-36.8\begin{array}{c}\text{CI}=[-62.0,-11.6]\\ p=4.48\text{e}-3^{\ast \ast }\end{array}$
		Space-shift		$\pm 0.55\begin{array}{c}\text{CI}=[0.28,0.82]\\ p=4.00\text{e}-4^{\ast \ast \ast }\end{array}$	$\pm 0.60\begin{array}{c}\text{CI}=[0.34,0.86]\\ p=3.89\text{e}-5^{\ast \ast \ast \ast }\end{array}$	$\pm 0.48\begin{array}{c}\text{CI}=[0.22,0.75]\\ p=2.24\text{e}-3^{\ast \ast }\end{array}$
	$\begin{array}{c}\text{APOE-}\epsilon 4\hfill \\ \text{carrier vs. non-carrier}\hfill \end{array}$	Accel. factor		$\times 1.17\begin{array}{c}\text{CI}=[1.02,1.33]\\ p=2.77\text{e}-2^{\ast }\end{array}$		$\times 1.42\begin{array}{c}\text{CI}=[1.12,1.82]\\ p=2.17\text{e}-2^{\ast }\end{array}$	$\times 1.25\begin{array}{c}\text{CI}=[1.03,1.51]\\ 2.17\text{e}-2^{\ast }\end{array}$
		Time-shift		$-45.0\begin{array}{c}\text{CI}=[-66.9,-23.2]\\ p=1.57\text{e}-4^{\ast \ast \ast }\end{array}$	$-36.8\begin{array}{c}\text{CI}=[-60.5,-13.0]\\ p=4.27\text{e}-3^{\ast \ast }\end{array}$
		Space-shift
Biological	$\begin{array}{c}\text{amyloid}\hfill \\ \text{positive vs. negative}\hfill \end{array}$	Accel. factor		$\times 1.18\begin{array}{c}\text{CI}=[1.06,1.32]\\ p=8.20\text{e}-3^{\ast \ast }\end{array}$	$\times 1.23\begin{array}{c}\text{CI}=[1.09,1.39]\\ p=4.03\text{e}-3^{\ast \ast }\end{array}$
		Time-shift					$-21.9\begin{array}{c}\text{CI}=[-41.2,-2.5]\\ p=2.70\text{e}-2^{\ast }\end{array}$
		Space-shift				$\pm 0.28\begin{array}{c}\text{CI}=[0.05,0.50]\\ p=2.24\text{e}-3^{\ast \ast }\end{array}$
Environmental	$\begin{array}{c}\text{marital}\hfill \\ \text{married vs. non-married}\hfill \end{array}$	Accel. factor		$\times 1.25\begin{array}{c}\text{CI}=[1.07,1.48]\\ p=1.08\text{e}-2^{\ast }\end{array}$
		Time-shift		$-59.5\begin{array}{c}\text{CI}=[-86.6,-32.5]\\ p=1.06\text{e}-4^{\ast \ast \ast }\end{array}$	$-52.7\begin{array}{c}\text{CI}=[-82.2,-23.2]\\ p=1.28\text{e}-3^{\ast \ast }\end{array}$		$-32.6\begin{array}{c}\text{CI}=[1.8,63.3]\\ p=3.78\text{e}-2^{\ast }\end{array}$
		Space-shift
	$\begin{array}{c}\text{education}\hfill \\ \text{nb. of years of education}\hfill \end{array}$	Accel. factor
		Time-shift		$-6.04\begin{array}{c}\text{CI}=[-9.67,-2.42]\\ p=1.95\text{e}-3^{\ast \ast }\end{array}$	$-7.60\begin{array}{c}\text{CI}=[-11.55,-3.64]\\ p=9.53\text{e}-4^{\ast \ast \ast }\end{array}$
		Space-shift