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. 2021 Apr 13;5:31. doi: 10.1038/s41698-021-00169-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b Correlation between experimental TMB and the TMB predicted according to our suggested panels for two reported cohorts of (a) melanoma (n = 174) and (b) NSCLC (n = 34) patients treated with ICB therapy (two melanoma samples with >6000 mutations are omitted for clarity). c Kaplan–Meier plot of OS in the 174 metastatic melanoma patients, stratified according to predicted TMB (cut-off, 150 mutations). d Kaplan–Meier plot of PFS in the 34 advanced NSCLC patients, stratified according to predicted TMB (cut-off, 150 mutations).