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. 2021 Apr 13;11:8060. doi: 10.1038/s41598-021-87539-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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No synergistic effects of linagliptin and Y2 receptor agonist treatment on oral glucose tolerance in DIO mice. An oral glucose tolerance test (OGTT) was performed one week before treatment start (day − 7, A,B) and on treatment day 12 (C,D). Horizontal lines denote significant change in blood glucose concentrations compared to vehicle control (p < 0.05, two-way ANOVA with Dunnett’s post-hoc test). *p < 0.05, linagliptin (3 mg/kg) + Y2R agonist (30 nmol/kg) vs. linagliptin (3 mg/kg), two-way ANOVA with Dunnett’s post-hoc test.