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. 2021 Apr 13;11:8085. doi: 10.1038/s41598-021-87526-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Small RNA sequencing (sRNAseq) results for RNA extracted from Vn96-isolated plasma EVs (n = 4). (a) Average number of reads ± SEM versus read length (bp). (b) Distribution of sRNA species in Vn96-isolated plasma EVs. (c) Regression plot of each patient miRNA result extracted by single parametric (SP) versus multiparametric (MP). (d) Top ten lowest variant miRNA (top) compared to their % of total miRNA abundance ± SEM (bottom). (e) Top 36 abundant miRNA expressed as % of total miRNA abundance ± SEM.