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. 2021 Apr 13;12:2195. doi: 10.1038/s41467-021-22504-6

Fig. 1. Artificial metabolic pathway for the direct production of 1,3-butadiene from glucose using the UbiX–UbiD system.

Fig. 1

prFMN is biosynthesized via UbiX from both FMN and DMAP and then binds to apo-FDC. FDC requires exposure to oxygen for enzymatic activity, whereas overexposure to oxygen causes loss of activity. PEP phosphoenolpyruvate, PTS PEP-dependent phosphotransferase system, ATP adenosine triphosphate, ADP adenosine diphosphate, G6P glucose-6-phosphate, E4P erythrose-4-phosphate, DAHP 3-deoxy-d-heptulosonate-7-phosphate, 3DHS 3-dehydroshikimate, PCA protocatechuic acid, CAT catechol, ccMA cis,cis-muconate, PA (Z)-pentadienoate, Phe l-phenylalanine, Tyr l-tyrosine, FDC ferulic acid decarboxylase, FMN flavin mononucleotide, DMAP dimethylallyl phosphate, prFMN prenylated FMN.