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. 2021 Apr 13;12:2208. doi: 10.1038/s41467-021-22458-9

Fig. 8. DMEs are enriched for TF-binding motifs and SNPs associated with immune-mediated diseases.

Fig. 8

a Significantly enriched TF-binding motifs in B1a and B2 DDMRs with varying patterns of methylation. Enriched motifs were filtered by p < 0.01 (binomial test run with HOMER) and a difference in motif instances between test and background sets of intervals greater than 5%; the entire set of DDMRs was used as the background. Motifs that are insensitive to CpG methylation or lack a CpG are depicted in black. Methylation-sensitive transcription factor binding motifs are marked in magenta and colored based on whether the colored by TF binding is enhanced (orange) or inhibited (cyan) by CpG methylation. b Enrichment of SNPs linked to human disease in GWAS in B lineage DMRs (red) and all HMRs excluding the DMRs (gray) calculated using RiVIERA. Source data are provided as a Source Data file.