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. 2021 Apr 13;12:2198. doi: 10.1038/s41467-021-22522-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a Expression of the four EFA6 gene isoforms in DCIS (ductal carcinoma in situ) compared to IDC (invasive ductal carcinoma). The p-values are for the Student’s t-test. b Expression of PSD4 is selectively decreased in the epithelial compartment of DCIS (n = 11). The p-values are for the Student’s t-test. c Ontologies associated with PSD4 knock-out in MCF10A cells (blue), and with the comparison of expression profiles of IDC versus DCIS samples in the Lee’s (orange) and Knudsen’s (green) data sets^33,34. d Expression of PSD4 is decreased in the metastatic samples versus the paired primary BC samples (n = 29). The corresponding primary BC–metastasis pairs are connected by thin colored lines. The p-value is for the paired Mann–Whitney test. Source data are provided as a Source Data file.