Table 3.

Results of Univariate and Multivariate Logistic Regression for Odds of NAC Receipt and Pathologic Overall Response (< ypT2N0) in Combined Institutional Cohort of Patients With MPC and CUC

MPC and CUC (N = 503)	NAC Receipt
	Univariate		Multivariate
Variable	OR (95% CI)	P	OR (95% CI)	P
Age ≥ 70 y	0.51 (0.35-0.75)	.001	0.53 (0.33-0.85)	.009
Female (assigned at birth)	1.41 (0.90-2.18)	.131	1.67 (0.98-2.85)	.059
ECOG PS > 1	1.82 (0.62-5.32)	.276	0.96 (0.23-3.96)	.955
cT3/4	5.24 (3.48-7.89)	<.001	6.92 (4.29-11.16)	<.001
GFR ≥ 60 mL/min	2.99 (1.83-4.88)	<.001	4.07 (2.26-7.32)	<.001
MPC component (any)	1.18 (1.05-1.32)	.007	1.22 (1.01-1.46)	.036
Patients Receiving NAC (N = 215)	Pathologic Overall Response (< ypT2N0)
Variable	OR (95% CI)	P	OR (95% CI)	P
Age ≥ 70 y	1.45 (0.77-2.74)	.257	1.54 (0.71-3.35)	.275
cT3/4	0.58 (0.33-1.00)	.050	0.47 (0.25-0.87)	.016
GFR ≥ 60 mL/min	1.09 (0.46-2.57)	.851	1.36 (0.53-3.54)	.524
MPC component (any)	0.94 (0.77-1.15)	.541	1.00 (0.80-1.24)	.962

Abbreviations: CI = confidence interval; cT = clinical tumor stage; CUC = conventional urothelial carcinoma; ECOG PS = Eastern Cooperative Oncology Group performance status; GFR = glomerular filtration rate; MPC = micropapillary carcinoma; NAC = neoadjuvant chemotherapy; OR = odds ratio; yp = pathologic stage after NAC receipt.