TABLE 1.

Cut-off values for the three core AD biomarkers with their 95% CI were calculated by maximizing the Youden’s index for AD vs. OND, between samples belonging to the AD clusters (cluster 3, 4, 5, and 6) and “control” cluster (cluster 1) and between samples belonging to the AD clusters and cluster 2.

	Aβ42/Aβ40	p-tau (pg/ml)	t-tau (pg/ml)
OND vs. AD	0.073 (0.063, 0.079)	53.5 (47.2, 57.5)	371 (332, 393)
Control cluster vs. AD clusters	0.072 (0.070, 0.074)	50.0 (46.2, 52.3)	392 (359, 396)
Cluster 2 vs. AD clusters	0.073 (0.072, 0.078)	71.6 (50.6, 82.8)	1403 (485, 1999)