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Comparison of sRNA-mediated gene silencing and CRISPRi.
| Characteristic | sRNA-mediated gene silencing | CRISPR interference |
| Silence type | post-transcriptional inhibition | transcription inhibition |
| Target | 5′ UTR of mRNA | promoter or the ORF of interested genes |
| Required tools | sRNA and chaperone protein (Hfq, etc.) | sgRNA and dCas9 |
| Common characteristics | silencing through base pairing of RNA and target, silence simultaneously multiple genes, programmable, off-target | |
