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iBMECs do not possess an endothelial transcriptional profile or vascular junctional components. iBMECs are shown to lack expression of phenotypical markers of a vascular EC lineage while expressing many epithelial cell lineage genes by bulk and single-cell RNA sequencing methods. The junctional components in iBMECs are also incongruent with canonical EC junctions leading to very serious concerns as to the efficacy of their use in an in vitro vascular BBB model.
