Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Overview of TFH cell differentiation and localization. The process of TFH cell differentiation highlights the chemokines needed for CD4+ T‐cell trafficking into the T‐cell and B‐cell zones. The expression of chemokine receptors on the surface of T cells plays a decisive role in the migration of TFH cells. CXCL13 is the ligand of CXCR5 and is secreted by B‐cell follicles and germinal centres. However, CCL19 and CCL21, the ligands of CCR7, are highly present in the T‐cell region.
