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. 2021 Apr 9;14:1341–1356. doi: 10.2147/JIR.S299927

Figure 5.

Figure 5

Genetic deletion of CR3 reverses the rotenone-induced imbalance of microglial M1/M2 polarization in mice. (A) Real-time PCR was performed to detect the mRNA levels of iNOS, TNFα and IL-1β in the brainstem of WT and CR3−/- mice. Results were mean ± SEM from six mice for each group and were analyzed by two-way ANOVA (iNOS: F(3,20) = 20.362, P = 0.000; TNFα: F(3,20) = 25.809, P=0.000; IL-1β: F(3,20) = 20.25, P = 0.000; post hoc analysis by Tamhane’s T2 multiple comparisons test). (B) The mRNA levels of Arg-1, CD206 and YM-1 in the brainstem of WT and CR3−/- mice were determined by real-time PCR. Results were mean ± SEM from six mice for each group. Data of Arg-1 were analyzed by Kruskal Wallis H-test (H(3) = 12.767, P = 0.005) and results of CD206 and YM-1 were analyzed by two-way ANOVA (CD206: F(3,20) = 2.235, P = 0.116, YM-1: F(3,20) = 1.768, P = 0.186). *P<0.05, **P<0.01.