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. 2021 Apr 9;14:1341–1356. doi: 10.2147/JIR.S299927

Figure 8.

Figure 8

CR3 deficiency or LA-1 treatment alleviates rotenone-induced degeneration of LC/NE neurons in mice. (A) Immunohistochemistry with an anti-TH antibody was performed to stain LC/NE neurons of rotenone-intoxicated WT and CR3−/- mice, and representative images are shown. (B) Quantification of the number of THir neurons. Results were mean ± SEM from five to six mice for each group and were analyzed by two-way ANOVA (F(3,19) = 6.923, P = 0.002, post hoc analysis by Tukey’s multiple comparisons test). (C) Immunohistochemistry with an anti-TH antibody was performed to stain LC/NE neurons of rotenone-intoxicated mice with or without LA-1 treatment, and representative images are shown. (D) Quantification of the number of THir neurons. Results were mean ± SEM from five mice for each group and were analyzed by one-way ANOVA (F(3,16) = 27.527, P = 0.000, post hoc analysis by Tukey’s multiple comparisons test). **P<0.01; Scale bar = 100 μm.