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. 2021 Mar 31;12:656097. doi: 10.3389/fimmu.2021.656097

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Copyright © 2021 Li, Zhang and Zeng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Meningeal γδ T cells involved in behavior regulation. Relying on CXCR6-CXCL16 axis, meningeal γδ T cells migrate to dura mater shortly after birth. Meningeal γδ T cells influence brain by constant secretion of IL-17. Neurons in medial prefrontal cortex(mPFC) and somatosensory cortex (S1DZ) express IL-17Ra in response to IL-17 to regulate anxiety-like behavior of mice. IL-17 induced glial brain-derived neurotrophic factor (BDNF) modulates hippocampal neuronal plasticity to maintain short-term memory.