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. 2021 Mar 31;12:664871. doi: 10.3389/fimmu.2021.664871

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Copyright © 2021 Yao, Cai, Ren, Ye, Wang, Zheng, Qian and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram of osteoimmunity. DLL4, delta-like protein 4; CAR, CXC chemokine ligand (CXCL) 12-abundant reticular; SCF, stem cell factor; HSC, hematopoietic stem cell; LepR, leptin receptor-expressing. Bone marrow mainly contains osteocytes, osteoblasts, osteoclasts, OsteoMacs and macrophages. OsteoMacs refers to the macrophages residing in the bone marrow, accounting for 15% to 20% of the total bone marrow cells. And they are mainly located near osteoblasts and support the generation of osteoblasts and bone formation. Macrophages are differentiated from monocytes derived from peripheral blood and further form osteoclasts. Bone is the cradle of immune cells, osteoclasts and osteoblasts are involved in regulating the immune response of a variety of immune cells. And they can also regulate the function of hematopoietic stem cells.