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. 2021 Mar 31;12:640718. doi: 10.3389/fimmu.2021.640718

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Copyright © 2021 Li, Riddle, Kumar, Poczobutt, McKeon, Frid, Ostaff, Reisz, Nemkov, Fini, Laux, Hu, El Kasmi, D’Alessandro, Brown, Zhang and Stenmark

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibiting CtBP1 reduced metabolites production in response to PH-CM. (A) Principle Component Analysis (PCA) showing clear separation of metabolites produced from BMDMs co-cultured with PH-Fibs with or without MTOB, CtBP1 inhibitor, treatment. (B) Heat-map showing in general the concentration of metabolites produced from BMDMs co-cultured with PH-Fibs in the presence of MTOB were decreased compared to in the absence of MTOB. Each column represents an individual sample. (C) Heat-map showing metabolites that are significantly changed in BMDMs with MTOB treatment (p ≤ 0.05).