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. 2021 Mar 26;24(4):102361. doi: 10.1016/j.isci.2021.102361

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This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Global and differential gene expression in spaceflight versus ground control liver samples from GeneLab datasets

(A and B) Principal component analysis of global gene expression in spaceflight (FLT) and respective ground control (GC) liver samples from the (A) Rodent Research 1 (RR-1) NASA Validation mission (GLDS-168) and (B) RR-6 ISS-terminal mission (GLDS-245). Plots were generated using data in the normalized counts tables for each respective dataset on the NASA GeneLab Data Repository.

(C and D) Heatmaps showing the top 30 differentially expressed genes in spaceflight (FLT) versus ground control (GC) liver samples from the (C) Rodent Research 1 (RR-1) NASA Validation mission (GLDS-168) and (D) RR-6 ISS-terminal mission (GLDS-245). Heatmaps were generated using data in the differential expression tables for each respective dataset on the NASA GeneLab Data Repository and are colored by relative expression. Adj. p value < 0.05 and |log2FC| > 1. All samples included were derived from frozen carcasses post-mission and utilized the ribo-depletion library preparation method.