Table 3.

Comparison of gene ontology in spaceflight versus ground control liver samples from GeneLab datasets

GeneLab dataset	# Enriched GO terms (NOM p < 0.01)	# Enriched GO terms (NOM p < 0.01 & FDR<0.5)	# Enriched GO terms (NOM p < 0.01 & FDR<0.25)
GLDS-168	71, 135	0, 132	0, 0
GLDS-245	21, 24	2, 6	1, 0

The number of enriched gene ontology (GO) terms identified by Gene Set Enrichment Analysis (GSEA, phenotype permutation) was evaluated in spaceflight (FLT) versus ground control (GC) liver samples from the Rodent Research 1 (RR-1) NASA Validation mission (GLDS-168), and RR-6 ISS-terminal mission (GLDS-245). For GO terms, the number on the left corresponds to GO terms enriched in FLT samples and the number on the right corresponds to GO terms enriched in GC samples. These data were generated using the normalized counts for each respective dataset on the NASA GeneLab Data Repository. All samples included were derived from frozen carcasses post-mission and utilized the ribo-depletion library preparation method. GLDS-168, FLT n = 5 and GC n = 5; GLDS-245, FLT n = 10 and GC n = 10. p values and FDR values are indicated.