Figure 6.

LINC00941 promoted NSCLC growth in vivo via miR-877-3p/VEGFA axis. A549 cells stably expressed LINC00941 were subcutaneously injected into right lower limb of the nude mice. 7 days later, agomiR-877-3p was injected through tail vein, or bevacizumab (10 mg/kg) was intraperitoneally injected. (A) Images of the representative excised tumors at 28 days after injection. (B) Tumor volume was measured every 7 days. (C) The ratio of tumor weigh to body weight was calculated. (D) The mRNA of LINC00941, miR-877-3p and VEGFA in isolated tumors were detected by qRT-PCR. (E) Ki67 staining used to detect the proliferation of isolated tumors. Data are mean ± SD; *P < 0.05 vs NC, ^#P < 0.05 vs LINC00941. All experiments were repeated three times.