Table 1.
Roles of Mondo family on body weight, hepatic steatosis and insulin sensitivity according to mouse models, depending on nutritional status, genetic background and drug administration.
| Mondo family | Context | Modulation in Mouse Models | Body Weight | Fat Mass | Hepatic Steatosis | Insulin Sensitivity | Reference |
|---|---|---|---|---|---|---|---|
| ChREBP | Standard diet | Global knockout | = | ↘ | = | ↘ | (32, 33) |
| Liver-specific knockout | = | ↘ | = | ↘ | (34) | ||
| Liver-specific overexpression | = | ↘ | ↗ | = | (35) | ||
| AT-specific knockout | = | = | ↘ | ↘ | (36) | ||
| AT-specific overexpression | ↘ | ↘ | = | = | (37) | ||
| Pancreatic β-cell-specific overexpression | ↘ | ND | ND | ↘ | (38) | ||
| Standard diet in ob/ob mice background | Global knockout | ↘ | ↘ | ↘ | ↗ | (33) | |
| Liver-specific knockdown | ↘ | ↘ | ↘ | ↗ | (39) | ||
| High-fat diet | Liver-specific knockout | = | = | = | ↘ | (34) | |
| Liver-specific overexpression | = | ↘ | ↗ | ↗ | (35) | ||
| AT-specific knockout | = | = | = | ↘ | (36) | ||
| AT-specific overexpression | ↘ | ↘ | ↘ | ↗ | (37) | ||
| Western diet | Global knockout | ↘ | ↘ | ↘ | ND | (40) | |
| High-carbohydrate diet | Liver-specific knockout | ↘ | ↘ | ↘ | ↘ | (34) | |
| HFrD | Global knockout | ↘ | ND | ↗ | ND | (41) | |
| Liver-specific knockout | ↘ | ↘ | = | ↗ | (42) | ||
| MondoA | Standard diet | Global knockout | = | ND | ND | = | (43) |
| Muscle-specific knockout | = | ND | ND | = | (44) | ||
| High-fat diet | Muscle-specific knockout | = | ND | ND | ↗ | (44) | |
| MondoA /ChREBP |
High-fat diet | Administration of a compound (SBI-993) that deactivates MondoA/ChREBP signaling | ↘ | ND | ↘ | ↗ | (45) |
“=“ means not changed. ND, not determined. The upward and downward arrows indicate an increase and decrease in the level, respectively.