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. 2021 Mar;10(3):1231–1238. doi: 10.21037/tlcr-20-1076

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2021 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Comparison of median TMB in treatment-naïve and treatment-experienced cohorts. TMB was compared in tumor specimen samples in treatment-naïve and treatment-experienced cohorts. There was no significant difference in TMB after adjusting for smoking status (P=0.21). When evaluating treatment versus no treatment within smoking cohorts, the p-values were 0.93, 0.04, and 0.69 for current smokers, former smokers, and never smokers respectively. The P values were calculated using the Wilcox rank test or chi-square test of deviance accordingly. Unknowns were excluded from P value calculations.