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. 2021 Mar;10(3):1231–1238. doi: 10.21037/tlcr-20-1076

Table 4. Comparison of TMB adjusted for presence of oncogene.

Treatment-Naïve Samples Treatment-Experienced Samples Adjusted P value
All oncogenes wild type
   n 707 119 0.124
   TMB median (mut/Mb) 9 9
Any oncogene mutated
   n 108 36 0.836
   TMB median (mut/Mb) 4.5 4

Oncogenes included in analysis are EGFR, ALK, ROS1, BRAF, RET, and NTRK. P values were assessed with Wilcoxon rank-sum test and adjusted for multiple testing.