Table 2. Expression of proteins involved in necroptosis and DNA damage response according to histology.
| Proteins | Level | SCC, n (%) | Non-SCC, n (%) | Chi-square value | P value |
|---|---|---|---|---|---|
| RIPK3 | Low | 89 (44.3) | 112 (55.7) | 5.401 | 0.026 |
| High | 107 (56.0) | 84 (44.0) | |||
| MLKL | Low | 115 (58.7) | 81 (41.3) | 12.178 | 0.001 |
| High | 80 (41.0) | 115 (59.0) | |||
| PELI1 | Low | 116 (59.5) | 79 (40.5) | 14.385 | <0.001 |
| High | 79 (40.3) | 117 (59.7) | |||
| p53 | Low | 83 (42.3) | 113 (57.7) | 8.902 | 0.003 |
| High | 112 (56.9) | 83 (42.1) | |||
| BRCA1 | Low | 102 (45.7) | 121 (54.3) | 3.730 | 0.067 |
| High | 95 (55.6) | 76 (44.4) | |||
| H2AX | Low | 96 (43.4) | 125 (56.6) | 8.667 | 0.004 |
| High | 101 (58.4) | 72(41.6) | |||
| ATM | Low | 103 (46.4) | 119 (53.6) | 2.642 | 0.127 |
| High | 94 (54.7) | 78 (45.3) | |||
| Chk2 | Low | 101 (40.4) | 149 (59.6) | 26.004 | <0.001 |
| High | 96 (67.1) | 47 (32.9) | |||
| ERCC1 | Low | 95 (41.3) | 135 (58.7) | 15.860 | <0.001 |
| High | 100 (61.7) | 62 (38.3) |
Expression of the proteins was classified as low and high by using a criterion of median value of all mean H-scores. P values obtained by chi-square test. SCC, squamous cell carcinoma.