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. 2021 Mar;10(3):1277–1291. doi: 10.21037/tlcr-20-1153

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2021 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Concurrent use of metformin with EGFR-TKIs augment apoptosis in TKI-resistant cells. (A) The synergistic pro-apoptosis effects of gefitinib (IC₂₅) combined with metformin (5 mM) on PC9R cells for 48 h, as determined by Annexin V/PI staining assay and FACS analysis. (B) Osimertinib (IC₂₅) and metformin (5 mM) synergistically enhanced the apoptosis of PC9R/OR cells after 48 h incubation, as assessed by Annexin V/PI staining assay. Statistical differences between groups were analyzed using one-way ANOVA (*P<0.05 compared with control).