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. 2021 Mar;10(3):1277–1291. doi: 10.21037/tlcr-20-1153

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2021 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Concurrent use of metformin improved survival of EGFR-mutant patients with advanced NSCLC and T2DM. (A) PFS1 stratified by metformin use in first-line EGFR-TKIs treatment. (B) OS1 stratified by metformin use in first-line EGFR-TKIs treatment. (C) PFS2 stratified by metformin use in second-line osimertinib treatment. (D) OS2 stratified by metformin use in second-line osimertinib treatment. Full line indicates patients who use metformin. Dotted line indicates patients who use hypoglycemic drugs other than metformin.