Skip to main content
. 2021 Mar 31;15:631485. doi: 10.3389/fncel.2021.631485

Table 2.

Astrocytic network parameters Ullah et al. (2006).

Parameter Parameter description Value
M × N Astrocytic network grid size 26 × 26
c0 Total Ca2+ in terms of cytosolic vol 2.0 μM
c1 (ER vol)/(cytosolic vol) 0.185
v1 Max Ca2+ channel flux 6 s−1
v2 Ca2+ leak flux constant 0.11 s−1
v3 Max Ca2+ uptake 2.2 μM s−1
v6 Maximum rate of activation-dependent calcium influx 0.2 μM s−1
k1 Rate constant of calcium extrusion 0.5 s−1
k2 Half-saturation constant for agonist-dependent calcium entry 1 μM
k3 Activation constant for ATP-Ca2+ pump 0.1 μM
d1 Dissociation constant for IP3 0.13 μM
d2 Dissociation constant for Ca2+ inhibition 1.049 μM
d3 Receptor dissociation constant for IP3 943.4 nM
d5 Ca2+ activation constant 82 nM
α 0.8
v4 Max rate of IP3 production 0.3 μM s−1
1/τr Rate constant for loss of IP3 0.14 s−1
IP3* Steady state concentration of IP3 0.16 μM
k4 Dissociation constant for Ca2+ stimulation of IP3 production 1.1 μM
dCa Ca2+ diffusion rate 0.05 s−1
dIP3 IP3 diffusion rate 0.1 s−1