. 2021 Mar 30;12:656350. doi: 10.3389/fimmu.2021.656350

Table 2.

IL-17A tissue expression and IL17A polymorphisms in all three groups.

Reference SNP^* and variation	IL17A Genotypes/IL-17A Tissue expression		COVID-19 (n = 20)^{†; §}		H1N1 (n = 10)^{†; §}		p-value¹	CONTROL (n = 11)^{†; §}		p-value²
Reference SNP^* and variation	IL17A Genotypes/IL-17A Tissue expression		Genotype	Tissue expression	Genotype	Tissue expression		Genotype	Tissue expression
rs3819025 G/A	Additive model	GG	3	2.9 (2.8–5.4)	0	N/A	0.186^a	0	N/A	0.170^a
		GA	7	3.2 (1.0–9.9)	2	0.1 (0.0–1.2)		7	0.0 (0.0–1.2)
		AA	9	0.8 (0.0–8.2)	8	0.1 (0.0–1.2)		3	0.0 (0.0–0.0)
	Dominant model	GG+GAAA	10	3.2 (1.0–9.9)	2	0.1 (0.0–1.2)	0.090^c	7	0.0 (0.0–1.2)	0.449^c
	Dominant model		9	0.8 (0.0–8.2)	8	0.1 (0.0–1.2)	0.090^c	3	0.0 (0.0–1.2)	0.449^c
	Recessive model	AA+GA	16	3.3 (0.0–9.9)	10	0.0 (0.0–0.2)	0.532^c	10	0.0 (0.0–0.2)	0.532^c
	Recessive model	GG	3	2.9 (2.8–5.4)	0	N/A	0.532^c	0	N/A	0.532^c

rs2275913 G/A	Additive model	GG	11	2.9 (0.0–8.2)	5	8.9 (4.3–11.0)	0.355^a	4	0.0 (0.0–0.0)	0.599^a
		GA	9	1.3 (0.0–9.9)	4	13.3 (5.3–15.4)		5	0.0 (0.0–0.0)
		AA	0	N/A	1	0.00 (0.0–0.0)		0	N/A
	Dominant model	GG+GA	20	1.3 (0.0–9.9)	9	10.5 (4.3–15.4)	0.333^c	9	0.0 (0.0–0.0)	–
	Dominant model	AA	0	N/A	1	0.0 (0.0–0.0)	0.333^c	0	N/A	–
	Recessive model	AA+GA	9	1.3 (0.0–9.9)	5	11.9 (5.3–15.4)	0.796^b	5	0.0 (0.0–0.0)	0.700^c
	Recessive model	GG	11	2.9 (0.0–8.2)	5	8.9 (4.3–11.0)	0.796^b	4	0.0 (0.0–0.0)	0.700^c

^*SNP identifier based on NCBI dbSNP; ^§ IL17A Genotypes were expressed by number; ^†Median (Minimum-Maximum) of IL-17A tissue expression. N/A, not applicable; Logistic regression^a, Pearson’s chi-square^b, or Fisher’s exact^c for ¹COVID-19 vs. H1N1 and ²COVID-19 vs. CONTROL.