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. 2021 Apr 14;47(5):538–548. doi: 10.1007/s00134-021-06388-0

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© Springer-Verlag GmbH Germany, part of Springer Nature 2021

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 2 — Univariable survival curves (Kaplan–Meier) of factors related to the 60-day outcome in critically ill patients who underwent advanced respiratory support. a Time periods estimated with the breakpoints of structure change (Period 1: February 27^th to April 25^th; Period 2: April 26^th to June 6^th; Period 3: June 7^th to August 10^th; Period 4: August 11^th to October 28^th); b age (< 40, 40–49, 50–59, 60–69, 70–79, and ≥ 80; c Modified Frailty Index (MFI) at the admission, with groups non-frail (MFI = 0), pre-frail (MFI = 1–2) and frail (MFI ≥ 3); and d initial respiratory support considering non-invasive (NIRS first) invasive (IMV first). Differences among curves were assessed using the log-rank test with a confidence level of 0.05.