Table 2.
Summary of the physiochemical properties of chelators that have been tested in PD models or patients.
| Name of chelator | Molecular weight | denticity | Log P (calc) | Tested in Parkinson's Models | Tested in Parkinson's Patients |
|---|---|---|---|---|---|
| Desferrioxamine (DFO) | 657 | hexadentate | –0.41 | – | – |
| Deferiprone | 139 | bidentate | –1.44 | [543,544]. | [496,542,544,545]. |
| Deferasirox | 373 | tridentate | 4.98 | [543]. | – |
| Pyridoxal isonicotinoyl hydrazone: (PIH) | 286 | tridentate | 0.43 | – | – |
| 5-[4-(2-hydroxyethyl) piperazine-1-ylmethyl]-quinoline-8-ol): (VK28) | 285 | bidentate | 3.68 | [522,523]. | – |
| N-(8-hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine: (M30) | 226 | bidentate | 1.89 | [523]. | – |
| 5-((Methylamino)methyl)-8-hydroxyquinoline): (Q1) | 188 | bidentate | 1.29 | [524]. | – |
| 5-Chloro-7-iodo-8-hydroxyquinoline: (clioquinol) | 305 | bidentate | 3.64 | [525,526]. | – |
| 1,3,5-tris[(3,4-dihydroxyphenethyl)carbamido]benzene: (Tris-dopamine ligand) | 616 | tris(bidentate) | 3.16 | – | – |
| (S)–N6-(2-(4-([2,2′-bipyridin]-5-yl)piperazin-1-yl)ethyl)-N6-Ethyl-4,5,6,7-tetrahydrobenzo [d]thiazole-2,6-diamine: (D607) | 478 | bidentate | 4.22 | [532,533]. | – |
| 5,7-Dichloro-2-((ethylamino)methyl)-8-hydroxy-3-methylquinazolin-4(3H)-one: (PBT434) | 302 | bidentate | 1.72 | [403]. | – |