Table 3.
Genotypic and allelic frequencies of the VDR gene polymorphisms among cases and controls
| Polymorphisms | Controls (N=160) (n%) | CAP (N=160) (n%) | Crude OR, 95% CI, p value |
|---|---|---|---|
| rs7975232 (ApaI) | |||
| CC | 65 (40.62) | 69 (43.12) | Ref |
| AC | 57 (35.62) | 60 (37.5) | 0.99 (0.60-1.62) 0.97 |
| AA | 38 (23.75) | 31 (19.37) | 0.76 (0.42-1.37) 0.37 |
| C | 187 (58.4) | 198 (62.0) | Ref |
| A | 133 (41.6) | 122 (38.0) | 0.86 (0.63-1.18) 0.37 |
| CC | 65 (40.62) | 69 (43.12) | Ref |
| AC+AA (Dominant) | 95 (59.38) | 91 (56.88) | 0.90 (0.57-1.40) 0.73 |
| CC+AA | 103 (64.37) | 100 (62.5) | Ref |
| AC (Over dominant) | 57 (35.63) | 60 (37.5) | 1.08 (0.68-1.70) 0.82 |
| CC+AC | 122 (76.25) | 129 (80.6) | Ref |
| AA (Recessive) | 38 (23.75) | 31 (19.4) | 0.77 (0.45-1.31) 0.34 |
| rs2228570 (FokI) | |||
| CC | 72 (45.0) | 47 (29.3) | Ref |
| CT | 60 (37.5) | 81 (50.62) | 2.06 (1.25-3.39) 0.00 |
| TT | 28 (17.5) | 32 (20.0) | 1.75 (0.93-3.27) 0.07 |
| C | 204 (63.75) | 175 (54.68) | Ref |
| T | 116 (36.25) | 145 (45.32) | 1.45(1.06-2.00) 0.02 |
| CC (Dominant) | 72 (45.0) | 47 (29.4) | Ref |
| CT+TT | 88 (55.0) | 113 (70.6) | 1.96 (1.24-3.12) 0.00 |
| CC+TT | 100 (62.5) | 79 (49.4) | Ref |
| CT (Over dominant) | 60 (37.5) | 81 (50.6) | 1.70 (1.09-2.66) 0.02 |
| CC+CT | 132 (82.5) | 128 (80.0) | Ref |
| TT (Recessive) | 28 (17.5) | 32 (20.0) | 1.17 (0.67-2.06) 0.56 |
| rs731236 (TaqI) | |||
| TT | 128 (80.0) | 120 (75.0) | Ref |
| TC | 22 (13.75) | 29 (18.1) | 1.40 (0.76-2.58) 0.27 |
| CC | 10 (6.25) | 11 (6.9) | 1.17 (0.48-2.86) 0.72 |
| T | 278 (87) | 269 (84.0) | Ref |
| C | 42 (13) | 51 (16.0) | 1.25 (0.80-1.95) 0.31 |
| TT (Dominant) | 128 (80.0) | 120 (75.0) | Ref |
| TC+CC | 32 (20.0) | 40 (25.0) | 1.33 (0.78-2.26) 0.28 |
| TT+CC | 138 (86.2) | 131 (81.9) | Ref |
| TC (Over dominant) | 22 (13.8) | 29 (18.1) | 1.38 (0.75-1.14) 0.28 |
| TT+TC | 150 (93.7) | 149 (93.1) | Ref |
| CC (Recessive) | 10 (6.3) | 11 (6.9) | 1.10 (0.45-2.68) 0.82 |
| rs154410 (BsmI) | |||
| GG | 119 (74.4) | 131 (81.87) | Ref |
| GA | 30 (18.7) | 19 (11.87) | 0.57 (0.30-1.07) 0.08 |
| AA | 11 (6.9) | 10 (6.25) | 0.82 (0.33-2.01) 0.67 |
| G | 268 (84.0) | 281 (88.0) | Ref |
| A | 52 (16.0) | 39 (12.0) | 0.71 (0.45-1.11) 0.14 |
| GG (Dominant) | 119 (74.4) | 131 (81.9) | Ref |
| GA+AA | 41 (25.6) | 29 (18.1) | 0.64 (0.37-1.09) 0.10 |
| GG+AA | 130 (81.3) | 141 (88.1) | Ref |
| GA (Over dominant) | 30 (18.7) | 19 (11.9) | 0.58 (0.31-1.08) 0.09 |
| GG+GA | 149 (93.1) | 150 (93.75) | Ref |
| AA (Recessive) | 11 (6.9) | 10 (6.25) | 0.90 (0.37-2.19) 0.82 |