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. 2021 Mar 29;9:633358. doi: 10.3389/fcell.2021.633358

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Copyright © 2021 Dong, Dong, Yang, Zhu, Gao, Chen, Zhao and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exosomal miR-3682-3p secreted by liver cancer cells suppressed HUVECs angiogenesis. (A) The microarray results were verified by qPCR. (B) The miR-3682-3p expressions in 8 frozen HCC tissues were generally decreased as compared with their corresponding normal tumor–adjacent tissues. (C–E) Tube formation assays (C), migration assays (D), and invasion assays (E) of HUVECs transfected with miR-3682-3p-mimic or negative control. Scale bar, 200 μm. (*p < 0.05; **i < 0.01; ***p < 0.001; ****p < 0.0001.)