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. 2021 Mar 29;11:592842. doi: 10.3389/fcimb.2021.592842

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Copyright © 2021 Duan, Liu, Fu, Lu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–H) Spearman’s correlation analysis between SCFA-producing bacteria and tight junction proteins and neuropsychological assessment of pAD groups. (A) Spearman’s correlation analysis outcome shows that the concentration of plasma claudin-1 was negatively correlated with the relative abundance of the SCFA-producing bacteria in the SCD group (r = −0.451, P = 0.024; Linear regression equation: Y = −224.0*X + 224.5, P = 0.0229). (B) Spearman’s correlation analysis outcome shows that the concentration of plasma claudin-1 was negatively correlated with the relative abundance of the SCFA-producing bacteria Ruminoclostridium9 in the SCD group (r = −0.398, P = 0.049; Linear regression equation: Y = −0.5602*X + 57.64, P = 0.0962). (C) Spearman’s correlation analysis between the relative abundance of SCFA-producing bacteria and AVLT-H (L) scores in the SCD group (r = 0.454, P = 0.023; Linear regression equation: Y = 3.847*X + 1.610, P = 0.2345). (D) Spearman’s correlation analysis between the concentration of plasma caludin-1 and AVLT-H (S) scores in the SCD group (r = 0.424, P = 0.034; Linear regression equation: Y = −0.008021*X + 5.555, P = 0.1623). (E) Spearman’s correlation analysis between the relative abundance of SCFA-producing bacteria and CDT30 in the aMCI group (r = 0.678, P = 0.004; Linear regression equation: Y = 12.68*X + 11.33, P = 0.1302). (F) Spearman’s correlation analysis between the relative abundance of SCFA-producing bacteria Ruminococcaceae5 and VFT scores in the aMCI group (r = 0.784, P= 0.000; Linear regression equation: Y = 0.01098*X + 13.63, P = 0.0359). (G) Spearman’s correlation analysis between the relative abundance of the SCFA-producing bacteria Ruminococcaceae13 and MoCA-B scores in the aMCI group (r = 0.772, P = 0.000; Linear regression equation: Y = 0.01652*X + 17.76, P = 0.0368). (H) Spearman’s correlation analysis between the relative abundance of the SCFA-producing bacteria Ruminococcaceae13 and VFT scores in the aMCI group (r = 0.773, P = 0.001; Linear regression equation: Y = 0.02425*X + 12.65, P = 0.019).