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. 2021 Mar 22;11:655700. doi: 10.3389/fcimb.2021.655700

Table 2.

Parasite and host substrates of parasitic CK1s.

Parasites CK1 Parasite substrates
Plasmodium falciparum
PfCK1
Name/phosphosite Function References
PfRON3 Rhoptry protein (Dorin-Semblat et al., 2015)
PfNapL Nucleosome assembly protein (Dorin-Semblat et al., 2015)
PfAlba4 DNA/RNA-binding protein (Dorin-Semblat et al., 2015)
Trypanosoma brucei
TbCK1.2
ZC3M11 RNA-binding protein (Minia and Clayton, 2016)
Leishmania donovani
LdCK1.2
Hsp90
Serine 289
Chaperone protein (Hombach-Barrigah et al., 2019)
Hsp70 Chaperone protein (Martel et al., 2020)
Hsp23 Chaperone protein (Kröber-Boncardo et al., 2020)
P23 Co-chaperone protein (Kröber-Boncardo et al., 2020)
Parasite
CK1
Host substrates
Name/phosphosite Function Reference
Leishmania
major
LmaCK1.2
IFNAR1
Serine 535
Subunit of the heterodimeric receptor complex for type 1 interferon signals (Liu et al., 2009)