FIGURE 2.

ASC-speck formation in LPS-primed and monomeric or aggregated α-synuclein–stimulated cells of PD and HC subjects. ASC-speck formation in unstimulated, LPS-stimulated, monomeric α-synuclein–stimulated, aggregated α-synuclein–stimulated, LPS-primed and monomeric α-synuclein–stimulated, or LPS-primed and aggregated α-synuclein–stimulated cells of 15 Parkinson disease (PD) patients and 15 healthy controls (HC). Summary results of ASC-speck–positive cells are shown in the bar graphs. The boxes stretch from the 25th to the 75th percentile; the line across the boxes indicates the median values; the lines stretching from the boxes indicate extreme values.