FIGURE 8.

IL-10 anti-inflammatory cytokine production by monomeric or aggregated α-synuclein–stimulated cells of PD and HC subjects. IL-10 production was analyzed in supernatants from PBMCs cultures of Parkinson disease (PD, n = 15) and healthy controls (HC, n = 15). PBMCs were unstimulated, LPS-stimulated, monomeric α-synuclein–stimulated, aggregated α-synuclein–stimulated, LPS-primed and monomeric α-synuclein–stimulated, or LPS-primed and aggregated α-synuclein–stimulated. Summary results are shown in the bar graphs. The boxes stretch from the 25th to the 75th percentile; the line across the boxes indicates the median values; the lines stretching from the boxes indicate extreme values.