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. 2021 Mar 25;9:637454. doi: 10.3389/fcell.2021.637454

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Copyright © 2021 Zhang, Zhang, Mo, Patel, Butterworth, Shao and Prise.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Micronucleus induction in non-irradiated bystander cells of HepG2 and T98G under hypoxic and normoxic conditions. The bystander cells were either co-cultured with irradiated conspecific cells (CC-O₂ and CC-N₂) or treated with the conditioned medium (CM-O₂ and CM-N₂) harvested from irradiated conspecific cells under the same oxygen conditions. The ratio of bystander micronucleus (A,B) to radiation-induced micronucleus of HepG2 cells (C) and T98G cells (D) under hypoxic and normoxic conditions was plotted. a, p < 0.05 compared with the 0-Gy group; b, p < 0.05 compared with the 2-Gy group; c, p < 0.05 compared with the normoxic group.