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. 2021 Mar 25;9:637454. doi: 10.3389/fcell.2021.637454

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Copyright © 2021 Zhang, Zhang, Mo, Patel, Butterworth, Shao and Prise.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of HIF-1α on the bystander effect of HepG2 cells and T98G cells under hypoxic conditions. Bystander tumor cells were treated with the conditioned medium harvested from irradiated conspecific cells, which were pretreated with HIF-1α siRNA and 5 μM 7-aminoflavone under hypoxic conditions. (A,C) Micronucleus induction in the bystander cells. (B,D) Survival fractions of bystander cells. a, p < 0.05 compared with the 0-Gy group; b, p < 0.05 compared between the 5-Gy group under different oxygen conditions.