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. 2021 Mar 25;9:637454. doi: 10.3389/fcell.2021.637454

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Copyright © 2021 Zhang, Zhang, Mo, Patel, Butterworth, Shao and Prise.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of HIF-1α and related downstream proteins on the bystander cells induced by the conditioned medium under hypoxic conditions. (A,B) Hypoxic bystander cells were treated with the conditioned medium from hypoxic-irradiated HepG2 and T98G cells. (C,D) Hypoxic bystander cells were exposed to the conditioned medium from irradiated cells with or without inhibitor pretreatment. Each HIF-1α signal and its downstream protein were compared with the corresponding β-actin signal and then normalized to that protein under hypoxia conditions. a, p < 0.05 compared with the hypoxic control without irradiation.