Skip to main content
. 2021 Mar 31;11:638363. doi: 10.3389/fonc.2021.638363

Figure 2.

Figure 2

Dynamics of promoter state’s changes of genes comprising GES of human embryonic MLME cells during human preimplantation embryogenesis. Graphs reflect the gradual transition from predominantly homogenously closed (silent) promoter state in the oocyte to predominantly homogenously open (active) promoter state at the morula stage. Homogenously open promoter states of genes comprising the MLME GES (18) are maintained in human embryonic cells of the ICM, TE, and hESC. Divergent promoter state definition refers to a transitional state of partially closed and partially open promoters. Promoter states of human genes at different stages of preimplantation embryogenesis were reported elsewhere (144).