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. 2021 Mar 31;11:638363. doi: 10.3389/fonc.2021.638363

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Copyright © 2021 Glinsky

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A model of SCARS expression dependence of oscillation patterns of loss and replenishment cycles of dying differentiated cells. (A) A model of the loss/replenishment cycle in the balanced state. (B) A model of the cycle at the prevalent loss of differentiated cells state. (C) A model of the cycle at the completed replenishment of differentiated cells state. (D) A model of the cycle with failed replenishment of differentiated cells due to failure of the SCARS silencing during attempts toward differentiation.