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. 2021 Mar 31;11:638363. doi: 10.3389/fonc.2021.638363

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Copyright © 2021 Glinsky

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Extracellular vesicles (EVs)—Guided regulation of tissue homeostasis cycles of the loss and replenishment of differentiated cells. (A) A model of tissue homeostasis at the loss of differentiated cells stage. (B) A model of tissue homeostasis at the stage of completed replenishment of the loss of differentiated cells. (C) Continuing maintenance of tissue homeostasis cycles is associated with fluctuations of distinct types of EVs. (D) A model of pathological states associated with altered tissue homeostasis due to the failure of differentiated cells replenishment.